AimThis study investigated the adjunctive effect of polydeoxyribonucleotide (PDRN) on bone formation in alveolar ridge preservation (ARP) sockets.Materials and MethodsBoth mandibular second, third and fourth premolars of eight beagle dogs were randomly divided into ARP and ARP/PDRN groups. Following tooth extraction, ARP procedures were conducted using collagenized alloplastic graft material and bilayer collagen membrane soaked with normal saline (ARP group) or PDRN (ARP/PDRN group) for 10 min before application. Both groups were also randomly allocated to 2‐, 4‐ or 12‐week healing subgroups. The primary endpoint of this study was to compare histomorphometric differences between ARP and ARP/PDRN. The secondary endpoints of this study were to compare micro‐CT analysis and three‐dimensional volumetric measurement between the two groups.ResultsIn the histomorphometric analysis, the ARP/PDRN group exhibited greater new bone formation at coronal, middle and total position compared with the ARP group at 2‐week healing. The number of newly formed blood vessels was higher in the ARP/PDRN group than in the ARP group at 2‐ and 4‐week healing. In micro‐CT analysis, the mean new bone volume/total bone volume between ARP and ARP/PDRN was statistically significant at 2‐week healing. Ridge volume alterations were significantly decreased in the ARP/PDRN group during entire healing time compared with the ARP group, especially on the buccal side.ConclusionsThe application of PDRN in ARP might provide additional benefits for early bone regeneration and maintenance of buccal ridge volume.

中文翻译：

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聚脱氧核糖核苷酸对牙槽嵴保存中骨形成的辅助作用：临床前体内研究

目的本研究探讨聚脱氧核糖核苷酸（PDRN）对牙槽嵴保留（ARP）牙槽窝骨形成的辅助作用。材料与方法将8只比格犬的下颌第二、第三和第四前磨牙随机分为ARP组和ARP/PDRN组。拔牙后，使用胶原化异体移植材料和双层胶原膜进行 ARP 手术，在应用前用生理盐水（ARP 组）或 PDRN（ARP/PDRN 组）浸泡 10 分钟。两组也被随机分配到 2 周、4 周或 12 周愈合亚组。本研究的主要终点是比较 ARP 和 ARP/PDRN 之间的组织形态学差异。本研究的次要终点是比较两组之间的显微 CT 分析和三维体积测量。结果在组织形态计量学分析中，与 ARP 相比，ARP/PDRN 组在冠状位、中间位和总位置表现出更多的新骨形成组在2周愈合时。愈合 2 周和 4 周时，ARP/PDRN 组新形成的血管数量高于 ARP 组。在显微 CT 分析中，ARP 和 ARP/PDRN 之间的平均新骨量/总骨量在 2 周愈合时具有统计学意义。与 ARP 组相比，ARP/PDRN 组在整个愈合时间内的牙槽嵴体积变化显着减少，尤其是颊侧。结论 PDRN 在 ARP 中的应用可能为早期骨再生和维持颊牙槽嵴体积提供额外的益处。