Coriander is a notable medicinal plant known for its diverse properties, including anti‐inflammatory, antioxidant, anticancer, analgesic, and anti‐diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic acid‐intoxicated zebrafish model. To assess kidney abnormalities induced by aristolochic acid (AA), we utilized the transgenic line Tg(wt1b:egfp), which expresses green fluorescent protein (GFP) in the kidney. Our previous report indicated that AA exposure leads to acute renal failure in zebrafish characterized by kidney malformation and impaired renal function. However, pretreatment of coriander extract (CE) can mitigate kidney malformations induced by AA. In addition, CE pretreatment reduces the accumulation of red blood cells in the glomerular region. To verify the nephroprotective effects of CE, we analyzed renal function by measuring the glomerular filtration rate in zebrafish embryos. Results indicate that CE partially mitigates renal function impairment caused by AA exposure, suggesting its potential to attenuate AA‐induced renal failure. Mechanistically, pretreatment with CE reduces the expression of proinflammatory and proapoptotic genes induced by AA. This suggests that CE likely alleviates acute renal failure by reducing inflammation and apoptosis. As a result, we regard zebrafish as a valuable model for screening natural compounds that have the potential to alleviate AA‐induced nephrotoxicity.

中文翻译：

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香菜（Coriandrum sativum）叶水提取物对马兜铃酸中毒的斑马鱼胚胎的肾保护作用

香菜是一种著名的药用植物，以其多种特性而闻名，包括抗炎、抗氧化、抗癌、镇痛和抗糖尿病作用。尽管其对健康有益，但对其肾保护特性的研究仍然有限。本研究旨在利用马兜铃酸中毒的斑马鱼模型研究香菜叶水提取物的潜在肾保护特性。为了评估马兜铃酸 (AA) 诱导的肾脏异常，我们利用了转基因品系 Tg(野生型1b：埃格菲普），在肾脏中表达绿色荧光蛋白（GFP）。我们之前的报告表明，AA 暴露会导致斑马鱼急性肾功能衰竭，其特征是肾脏畸形和肾功能受损。然而，香菜提取物（CE）的预处理可以减轻AA引起的肾脏畸形。此外，CE预处理减少了肾小球区域红细胞的积累。为了验证 CE 的肾保护作用，我们通过测量斑马鱼胚胎的肾小球滤过率来分析肾功能。结果表明，CE 部分减轻了 AA 暴露引起的肾功能损伤，表明其有可能减轻 AA 引起的肾功能衰竭。从机制上讲，CE 预处理可减少 AA 诱导的促炎和促凋亡基因的表达。这表明 CE 可能通过减少炎症和细胞凋亡来缓解急性肾衰竭。因此，我们认为斑马鱼是筛选具有减轻 AA 引起的肾毒性潜力的天然化合物的有价值的模型。