Staphylococcus aureus (S. aureus) is an opportunistic pathogen of the gram-positive variety, known to cause a range of severe infections including cellulitis, pneumonia, osteomyelitis, endocarditis, and sepsis. These infections are associated with significant morbidity and mortality rates in both hospital and community settings. Therefore, it is important to remove S. aureus from the aqueous solution. The present study employed response surface methodology as an effective strategy to optimize the removal of S. aureus through the electro-Fenton (EF), UV/H₂O₂, and combination EF-UV/H₂O₂ processes. Under the optimized conditions, the maximum removal efficiency in the EF process of 48.5%, UV/H₂O₂ process of 36.2%, and combination EF-UV/H₂O₂ process of 100%. The optimum condition for removal efficiency using combination EF-UV/H₂O₂ process of 100% was attained at S. aureus concentration of 5 × 10⁶ CFU mL⁻¹, current density of 8.0 mA cm⁻², H₂O₂ dosage of 170 µL L⁻¹, and 2 lamps UV during 7.0 min. Both the production of ^•OH in the EF and UV/H₂O₂ process and the additive oxidation effect of UV/H₂O₂ are the main reasons for the better performance of combination EF-UV/H₂O₂ process. The results indicate that the EF-UV/H₂O₂ process is highly promising and environmentally sustainable method for treating wastewater samples contaminated with S. aureus.

金黄色葡萄球菌( S. aureus ) 是一种革兰氏阳性机会致病菌，已知会引起一系列严重感染，包括蜂窝组织炎、肺炎、骨髓炎、心内膜炎和败血症。这些感染与医院和社区环境中的显着发病率和死亡率相关。因此，从水溶液中去除金黄色葡萄球菌很重要。本研究采用响应面法作为有效策略，通过电芬顿 (EF)、UV/H ₂ O ₂和组合 EF-UV/H ₂ O ₂工艺优化金黄色葡萄球菌的去除。优化条件下，EF工艺的最大去除效率为48.5%，UV/H ₂ O ₂工艺的最大去除效率为36.2%，EF-UV/H ₂ O ₂组合工艺的最大去除效率为100%。当金黄色葡萄球菌浓度为5 × 10 ⁶ CFU mL ^-1、电流密度为8.0 mA cm ^-2、H ₂ O _{2时，EF-UV/H 2} O ₂组合工艺去除效率达到100%的最佳条件7.0 分钟期间，剂量为 170 µL L ^-1和 2 盏 UV 灯。EF和UV/H ₂ O _2工艺中^• OH的产生以及UV/H ₂ O ₂的附加氧化作用是EF-UV/H ₂ O ₂组合工艺性能更好的主要原因。结果表明，EF-UV/H ₂ O _{2工艺是处理}金黄色葡萄球菌污染废水样品的非常有前途且环境可持续的方法。