Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency period between exposure and health outcome, potentially placing a large number of individuals at risk of these health consequences. Emerging evidence suggests that environmental exposures in early life may be key risk factors for cardiovascular conditions across the life span. Children are a particularly sensitive population for the detrimental effects of environmental toxicants and pollutants given the long-term cumulative effects of early-life exposures on health outcomes, including congenital heart disease, acquired cardiac diseases, and accumulation of cardiovascular disease risk factors. This scientific statement highlights representative examples for each of these cardiovascular disease subtypes and their determinants, focusing specifically on the associations between climate change and congenital heart disease, airborne particulate matter and Kawasaki disease, blood lead levels and blood pressure, and endocrine-disrupting chemicals with cardiometabolic risk factors. Because children are particularly dependent on their caregivers to address their health concerns, this scientific statement highlights the need for clinicians, research scientists, and policymakers to focus more on the linkages of environmental exposures with cardiovascular conditions in children and adolescents.

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环境暴露与儿科心脏病学：美国心脏协会的科学声明

环境毒物和污染物是造成不良健康后果的原因，其中包括环境暴露与心血管疾病之间的明确关联。环境退化广泛存在，并且在接触环境和产生健康结果之间有很长的潜伏期，可能使大量个人面临这些健康后果的风险。新的证据表明，生命早期的环境暴露可能是一生中心血管疾病的关键危险因素。儿童是对环境毒物和污染物的有害影响特别敏感的人群，因为早期接触环境毒物和污染物会对健康结果产生长期累积影响，包括先天性心脏病、后天性心脏病和心血管疾病危险因素的积累。该科学声明重点介绍了每种心血管疾病亚型及其决定因素的代表性实例，特别关注气候变化与先天性心脏病、空气颗粒物与川崎病、血铅水平和血压以及内分泌干扰化学物质之间的关联。心脏代谢危险因素。由于儿童特别依赖照顾者来解决他们的健康问题，这一科学声明强调临床医生、研究科学家和政策制定者需要更多地关注环境暴露与儿童和青少年心血管疾病的联系。