Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results,Alzheimer's & Dementia

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Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2024-04-16 , DOI: 10.1002/alz.13750
Maurice Pasternak _{1,

2} , Saira S. Mirza ₁ , Nicholas Luciw _{1,

3} , Henri J. M. M. Mutsaerts ₄ , Jan Petr ₅ , David Thomas ₆ , David Cash ₇ , Martina Bocchetta ₇ , Maria Carmela Tartaglia _{8,

9,

10} , Sara B. Mitchell ₁₀ , Sandra E. Black _{10,

11,

12} , Morris Freedman _{10,

11} , David Tang‐Wai _{10,

11,

13} , Ekaterina Rogaeva ₈ , Lucy L. Russell ₇ , Arabella Bouzigues ₆ , John C. van Swieten ₁₄ , Lize C. Jiskoot ₁₄ , Harro Seelaar ₁₄ , Robert Laforce ₁₅ , Pietro Tiraboschi ₁₆ , Barbara Borroni ₁₇ , Daniela Galimberti _{18,

19} , James B. Rowe _{20,

21,

22} , Caroline Graff _{23,

24} , Elizabeth Finger ₂₅ , Sandro Sorbi _{26,

27} , Alexandre de Mendonça ₂₈ , Chris Butler _{29,

30} , Alex Gerhard _{31,

32,

33} , Raquel Sanchez‐Valle ₃₄ , Fermin Moreno _{35,

36} , Matthis Synofzik ₃₇ , Rik Vandenberghe ₃₈ , Simon Ducharme _{39,

40} , Johannes Levin _{41,

42} , Markus Otto ₄₃ , Isabel Santana ₄₄ , Antonio P. Strafella _{13,

45,

46} , Bradley J. MacIntosh _{1,

3} , Jonathan D. Rohrer ₇ , Mario Masellis _{1,

2,

10,

12,

47} ,

Affiliation

Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Ontario Canada
Institute of Medical Science Temerty Faculty of Medicine University of Toronto Toronto Ontario Canada
Medical Biophysics University of Toronto Toronto Ontario Canada
Department of Radiology and Nuclear Medicine Amsterdam Neuroscience Amsterdam University Medical Center Amsterdam the Netherlands
Helmholtz‐Zentrum Dresden‐Rossendorf Institute of Radiopharmaceutical Cancer Research Dresden Germany
Department of Brain Repair and Rehabilitation UCL Queen Square Institute of Neurology Queen Square London UK
Dementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology Queen Square London UK
Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada
Memory Clinic University Health Network Toronto Ontario Canada
Division of Neurology Department of Medicine Sunnybrook Health Sciences Centre Toronto Ontario Canada
Rotman Research Institute Baycrest Health Sciences Toronto Ontario Canada
Cognitive Neurology Research Unit Sunnybrook Health Sciences Centre Toronto Ontario Canada
Krembil Research Institute University Health Network Toronto Ontario Canada
Department of Neurology Erasmus Medical Center Rotterdam the Netherlands
Clinique Interdisciplinaire de Mémoire CHU de Québec, Département des Sciences Neurologiques Université Laval Quebec Quebec Canada
Division of Neurology Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy
Department of Clinical and Experimental Sciences University of Brescia Brescia Italy
Department of Biomedical Surgical and Dental Sciences University of Milan Milan Italy
Neurodegenerative Diseases Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Department of Clinical Neurosciences University of Cambridge Cambridge UK
Cambridge University Hospitals NHS Trust University of Cambridge Cambridge UK
Medical Research Council Cognition and Brain Sciences Unit University of Cambridge Cambridge UK
Department of Neurobiology Care Sciences and Society Karolinska Institutet Huddinge Sweden
Unit for Hereditary Dementias Karolinska University Hospital Solna Sweden
Department of Clinical Neurological Sciences Western University London Ontario Canada
Department of Neurofarba University of Florence Florence Italy
Fondazione Don Carlo Gnocchi Istituto di Ricovero e Cura a Carattere Scientifico Florence Italy
Neurology Department Faculty of Medicine University of Lisbon Lisbon Portugal
Nuffield Department of Clinical Neurosciences Medical Sciences Division University of Oxford Oxford UK
Department of Brain Sciences Imperial College London London UK
Division of Psychology Communication and Human Neuroscience Wolfson Molecular Imaging Centre University of Manchester Manchester UK
Department of Geriatric Medicine Klinikum Hochsauerland GmbH Arnsberg Germany
Department of Nuclear Medicine Center for Translational Neuro‐ and Behavioral Sciences University Hospital Essen Essen Germany
Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Clinic de Barcelona Barcelona Spain
Cognitive Disorders Unit Department of Neurology Donostia University Hospital Gipuzkoa Building Begiristain Doktorea Pasealekua Donostia–San Sebastian Gipuzkoa Spain
Neuroscience Area Biodonostia Health Research Institute Donostia–San Sebastian Gipuzkoa Spain
Department of Neurodegenerative Diseases Hertie‐Institute for Clinical Brain Research and Center of Neurology University of Tübingen Tübingen Germany
Laboratory for Cognitive Neurology Department of Neurosciences KU Leuven Leuven Belgium
Department of Psychiatry Douglas Mental Health University Institute McGill University Montreal Quebec Canada
McConnell Brain Imaging Centre Montreal Neurological Institute and Hospital Montreal Quebec Canada
Department of Neurology Ludwig‐Maximilians‐University Munich Germany
Munich Cluster of Systems Neurology (SyNergy) Munich Germany
Department of Neurology University of Ulm Ulm Germany
Center for Neuroscience and Cell Biology Faculty of Medicine University of Coimbra Coimbra Portugal
Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto Ontario Canada
Edmond J. Safra Parkinson Disease Program & Morton and Gloria Shulman Movement Disorder Unit Toronto Western Hospital UHN Toronto Ontario Canada
Department of Medicine Division of Neurology University of Toronto Toronto Ontario Canada

Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers.

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