In cancer treatment, the recurrent challenge of inducing apoptosis through conventional therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to explore alternative cell death pathways. Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides on cellular membranes, has emerged as one such promising frontier in oncology. Induction of ferroptosis not only suppresses tumor growth but also holds potential for augmenting immunotherapy responses and surmounting resistance to existing cancer therapies. This review navigates the role of ferroptosis in tumor suppression. Furthermore, we delve into the complex role of ferroptosis within the tumor microenvironment and its interplay with antitumor immunity, offering insights into the prospect of targeting ferroptosis as a strategic approach in cancer therapy.

在癌症治疗中，通过传统治疗方式诱导细胞凋亡的反复挑战（常常因治疗耐药性而受阻）强调了探索替代细胞死亡途径的迫切需要。铁死亡是一种由细胞膜上致命的脂质过氧化物积累引发的铁依赖性受调节细胞死亡形式，已成为肿瘤学中一个充满希望的前沿领域。铁死亡的诱导不仅可以抑制肿瘤生长，而且还具有增强免疫治疗反应和克服对现有癌症治疗的耐药性的潜力。这篇综述探讨了铁死亡在肿瘤抑制中的作用。此外，我们深入研究了铁死亡在肿瘤微环境中的复杂作用及其与抗肿瘤免疫的相互作用，为将铁死亡作为癌症治疗的战略方法的前景提供了见解。