In this issue of Cancer Cell, Spitzer and colleagues demonstrate the role of IDH inhibitors on IDHmutant gliomas in reducing proliferation and enhancing cell differentiation toward an astrocytic-like state, thus altering neurodevelopmental pathways. Despite clinical promise, unresolved questions regarding mechanisms of action and resistance underline the need for further research for treatment optimization.

中文翻译：

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改变格局：IDH 抑制剂在神经胶质瘤细胞命运中的作用

在本期《Cancer Cell 》中，Spitzer 及其同事证明了 IDH 抑制剂对 IDH 突变神经胶质瘤的作用，可减少增殖并增强细胞向星形细胞样状态的分化，从而改变神经发育途径。尽管有临床前景，但有关作用机制和耐药性的尚未解决的问题强调需要进一步研究以优化治疗。