The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive. This study retrospectively included 24,871 participants in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Weighted logistic regression was performed to investigate the connection between OA and hypertension. Additionally, Mendelian randomization (MR) analysis was conducted to explore the potential causal relationship between OA and hypertension. In the NHANES data, after adjusting for multiple confounding factors, there was no significant relationship between OA and hypertension (OR 1.30, 95% CI, 0.97–1.73, P = 0.089). However, among males, OA appeared to be associated with a higher risk of hypertension (OR 2.25, 95% CI, 1.17–4.32, P = 0.019). Furthermore, MR results indicate no relationship between multiple OA phenotypes and hypertension: knee OA (IVW, OR 1.024, 95% CI: 0.931–1.126, P = 0.626), hip OA (IVW, OR 0.990, 95% CI: 0.941–1.042, P = 0.704), knee or hip OA (IVW, OR 1.005, 95% CI: 0.915–1.105, P = 0.911), and OA from UK Biobank (IVW, OR 0.796, 95% CI: 0.233–2.714, P = 0.715). Importantly, these findings remained consistent across different genders and in reverse MR. Our study found that OA patients had a higher risk of hypertension only among males in the observational study. However, MR analysis did not uncover any causal relationship between OA and hypertension.

中文翻译：

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骨关节炎和高血压：观察性和孟德尔随机分析

骨关节炎（OA）和高血压之间的关联是观察性研究中持续争论的一个话题，而它们之间的潜在因果关系仍然难以捉摸。这项研究回顾性地纳入了 2013 年至 2020 年国家健康和营养检查调查 (NHANES) 的 24,871 名参与者。采用加权逻辑回归来研究 OA 与高血压之间的关系。此外，还进行了孟德尔随机化 (MR) 分析，以探讨 OA 与高血压之间的潜在因果关系。在NHANES数据中，调整多种混杂因素后，OA与高血压之间没有显着关系（OR 1.30，95% CI，0.97-1.73，P = 0.089）。然而，在男性中，OA 似乎与较高的高血压风险相关（OR 2.25，95% CI，1.17-4.32，P = 0.019）。此外，MR 结果表明多种 OA 表型与高血压之间没有关系：膝部 OA（IVW，OR 1.024，95% CI：0.931–1.126，P = 0.626）、髋部 OA（IVW，OR 0.990，95% CI：0.941–1.042） ，P = 0.704），膝关节或髋关节 OA（IVW，OR 1.005，95% CI：0.915–1.105，P = 0.911），以及来自 UK Biobank 的 OA（IVW，OR 0.796，95% CI：0.233–2.714，P = 0.715）。重要的是，这些发现在不同性别和反向 MR 中保持一致。我们的研究发现，在观察性研究中，仅男性中 OA 患者患高血压的风险较高。然而，MR 分析并未发现 OA 与高血压之间存在任何因果关系。