sing a large-scale epidemiological cohort. Methods We retrospectively analyzed 4,311,393 adults enrolled in the JMDC Claims Database (previously known as the Japan Medical Data Center database), a nationwide epidemiological database in Japan. The definitions of IgA nephropathy and inflammatory bowel disease (ulcerative colitis or Crohn’s disease) were based on International Classification of Diseases-10th Revision codes. Individuals who had a prior history of IgA nephropathy were excluded. Study participants were categorized into two groups according to the presence of inflammatory bowel disease. Clinical outcomes were collected between January 2005 and May 2022. The primary outcome was incident IgA nephropathy. Results Median (interquartile range) age was 44 (36-53) years, and 2,497,313 (58%) were men. Inflammatory bowel disease was observed in 18,623 individuals (0.4%). Over a median follow-up of 1,089 (532–1,797) days, there were 2,631 incidences of IgA nephropathy and 22 incidences in individuals without and with inflammatory bowel disease, yielding incident ratios with 95% confidence intervals of 1.74 (1.68-1.81) and 3.43 (2.26-5.21), respectively. Kaplan-Meier curves and the log-rank test showed that a cumulative incidence of IgA was higher in individuals with inflammatory bowel disease compared to those without (log-rank p=0.003). Multivariable Cox regression analysis demonstrated that individuals with inflammatory bowel disease were at higher risk for incident IgA nephropathy (Hazard ratio 1.96, 95% confidence interval 1.29-2.99). Conclusions We demonstrated the potential association of inflammatory bowel disease with higher risk of developing IgA nephropathy in a general population. Copyright © 2024 by the American Society of Nephrology...

中文翻译：

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炎症性肠病与免疫球蛋白 A 肾病的关联

进行大规模流行病学队列研究。方法 我们回顾性分析了日本全国流行病学数据库 JMDC 索赔数据库（以前称为日本医疗数据中心数据库）中登记的 4,311,393 名成年人。 IgA 肾病和炎症性肠病（溃疡性结肠炎或克罗恩病）的定义基于国际疾病分类第 10 版修订代码。有 IgA 肾病病史的个体被排除在外。根据是否存在炎症性肠病，研究参与者被分为两组。收集 2005 年 1 月至 2022 年 5 月期间的临床结果。主要结果是发生 IgA 肾病。结果 中位年龄（四分位距）为 44 (36-53) 岁，其中 2,497,313 名 (58%) 为男性。 18,623 人 (0.4%) 中观察到炎症性肠病。在中位随访 1,089 (532–1,797) 天中，IgA 肾病发病率为 2,631 例，无炎症性肠病和患有炎症性肠病的个体中有 22 例发病，发生率的 95% 置信区间为 1.74 (1.68-1.81)，分别为 3.43 (2.26-5.21)。 Kaplan-Meier 曲线和对数秩检验表明，与没有炎症性肠病的个体相比，患有炎症性肠病的个体 IgA 的累积发生率更高（对数秩 p=0.003）。多变量 Cox 回归分析表明，患有炎症性肠病的个体发生 IgA 肾病的风险较高（风险比 1.96，95% 置信区间 1.29-2.99）。结论 我们证明了一般人群中炎症性肠病与患 IgA 肾病的较高风险之间存在潜在关联。版权所有 © 2024 美国肾脏病学会...