Hematopoietic stem cells (HSCs) are instrumental for organismal survival because they are responsible for lifelong production of mature blood lineages in homeostasis and response to external stress. To fulfill their function, HSCs rely on reciprocal interactions with specialized tissue microenvironments, termed HSC niches. From embryonic development to advanced aging, HSCs transition through several hematopoietic organs in which they are supported by distinct extrinsic cues. Here, we describe recent discoveries on how HSC niches collectively adapt to ensure robust hematopoietic function during biological aging and after exposure to acute stress. We also discuss the latest strategies leveraging niche-derived signals to revert aging-associated phenotypes and enhance hematopoietic recovery after myeloablation.

中文翻译：

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造血干细胞的骨髓生态位：寿命动态和对急性应激的适应


造血干细胞（HSC）对于生物体的生存至关重要，因为它们负责在体内平衡和对外部压力的反应中终身产生成熟的血统。为了实现其功能，HSC 依赖于与特殊组织微环境（称为 HSC 生态位）的相互作用。从胚胎发育到晚期衰老，造血干细胞通过几个造血器官进行转变，在这些器官中它们受到不同的外在信号的支持。在这里，我们描述了关于 HSC 生态位如何集体适应以确保在生物衰老期间和暴露于急性应激后强大的造血功能的最新发现。我们还讨论了利用生态位衍生信号来恢复衰老相关表型并增强清髓后造血恢复的最新策略。