Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.¹ find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.

中文翻译：

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游离核糖体蛋白是核仁应激的罪魁祸首

核仁应激一直与年龄相关疾病有关。在本期中，Sirozh 等人。¹发现核仁应激的共同分子特征是游离核糖体蛋白的积累，从而导致小鼠过早衰老；然而，它可以通过抑制 mTOR 来逆转。