Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasmacytoid is associated with more aggressive clinical behaviour than conventional carcinoma. Advances in molecular profiling led to the identification of molecular subtypes of bladder cancer and provided insights into disease progression to aggressive variants.

中文翻译：

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膀胱癌变体——一种有多种面孔的疾病

膀胱癌发展为肉瘤样癌、小细胞癌、微乳头状癌和浆细胞样癌等微观上不同的变异，与传统癌症相比更具侵袭性的临床行为相关。分子谱分析的进步导致了膀胱癌分子亚型的鉴定，并为疾病进展到侵袭性变异提供了见解。