Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour progression not only by providing cancer cells with increased proliferative potential and an improved ability to adapt to adverse microenvironmental conditions but also by favouring the evasion of natural and therapy-driven antitumour immune responses. Here, we review cancer cell-intrinsic and cancer cell-extrinsic mechanisms through which alterations of metabolism in malignant cells interfere with innate and adaptive immune functions in support of accelerated disease progression. Further, we discuss the potential of targeting such alterations to enhance anticancer immunity for therapeutic purposes.

越来越多的证据表明，恶性细胞中的代谢重连不仅通过为癌细胞提供增加的增殖潜力和提高适应不利微环境条件的能力来支持肿瘤进展，而且还通过有利于逃避自然和治疗驱动的抗肿瘤免疫反应。在这里，我们回顾了癌细胞内在和癌细胞外在机制，恶性细胞代谢的改变通过这些机制干扰先天和适应性免疫功能，从而支持加速疾病进展。此外，我们还讨论了针对此类改变增强抗癌免疫力以达到治疗目的的潜力。