Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent studies have also highlighted the role of increased lipogenesis in kidney fibrosis. The defect in fatty acid oxidation causes energy starvation. Increased lipid uptake, synthesis, and lower fatty acid oxidation can cause toxic lipid build-up, reactive oxygen species generation, and mitochondrial damage. A better understanding of these metabolic processes may open new treatment avenues for kidney diseases by targeting lipid metabolism.

中文翻译：

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肾小管细胞脂质代谢改变在肾脏疾病发展中的关键作用


肾上皮细胞具有非常高的能量需求，这主要通过脂肪酸氧化来满足。在肾病患者中观察到脂质代谢的复杂变化。脂肪酸氧化缺陷和脂质摄取增加，特别是在高脂血症和蛋白尿的情况下，会导致脂质过量积聚并加剧肾脏疾病的发展。最近的研究还强调了脂肪生成增加在肾纤维化中的作用。脂肪酸氧化的缺陷导致能量匮乏。脂质摄取、合成和脂肪酸氧化降低会导致有毒脂质积聚、活性氧生成和线粒体损伤。更好地了解这些代谢过程可能会通过靶向脂质代谢为肾脏疾病开辟新的治疗途径。