Gene expression in the human cortex is shown to exhibit a generalizable three-component architecture that reflects neuronal, metabolic, and immune programmes of healthy brain development. The three components have distinct associations with autism spectrum disorder and schizophrenia, revealing connections between previously unrelated results from studies of case–control neuroimaging, differential gene expression, and genetic risk.

中文翻译：

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将大脑组织与健康和疾病基因联系起来的三种模式

人类皮质中的基因表达表现出可概括的三部分结构，反映了健康大脑发育的神经元、代谢和免疫程序。这三个组成部分与自闭症谱系障碍和精神分裂症具有明显的关联，揭示了病例对照神经影像、差异基因表达和遗传风险研究中先前不相关的结果之间的联系。