Electrical neuromodulation has achieved significant translational advancements, including the development of deep brain stimulators for managing neural disorders and vagus nerve stimulators for seizure treatment. Optoelectronics, in contrast to wired electrical systems, offers the leadless feature that guides multisite and high spatiotemporal neural system targeting, ensuring high specificity and precision in translational therapies known as “photoelectroceuticals”. This Account provides a concise overview of developments in novel optoelectronic nanomaterials that are engineered through innovative molecular, chemical, and nanostructure designs to facilitate neural interfacing with high efficiency and minimally invasive implantation.

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探索纳米增强光电神经调节的当前和未来方向

电神经调节已经取得了重大的转化进步，包括开发用于治疗神经疾病的深部脑刺激器和用于癫痫治疗的迷走神经刺激器。与有线电气系统相比，光电子学提供无引线功能，可引导多部位和高时空神经系统靶向，确保称为“光电子药物”的转化疗法的高特异性和精确度。本报告简要概述了新型光电纳米材料的发展，这些材料通过创新的分子、化学和纳米结构设计进行工程设计，以促进高效和微创植入的神经接口。