SSRIs are among the most frequently prescribed antidepressants, at least in part because of their favourable safety profile. However, serotoninergic mechanisms are involved in haemostasis, and the potential adverse effects of these drugs may have been underestimated. A study used a UK primary care database to compare the risk of major bleeding in people already taking SSRIs who were starting oral anticoagulants because of atrial fibrillation with controls using oral anticoagulants alone. Risk of bleeding increased by 33% in the first few months for people taking both SSRIs and oral anticoagulants ( JAMA Netw Open doi:10.1001/jamanetworkopen.2024.3208). A retrospective study in France which reviewed 300 patients who fulfilled criteria …

中文翻译：

---

SSRIs 和抗凝剂。 。 。和其他故事

SSRIs 是最常用的抗抑郁药之一，至少部分是因为其良好的安全性。然而，血清素能机制参与止血，这些药物的潜在副作用可能被低估了。一项研究使用英国初级保健数据库来比较已经服用 SSRI 的患者因房颤而开始口服抗凝剂的患者与仅使用口服抗凝剂的对照者的大出血风险。同时服用 SSRI 和口服抗凝剂的人在最初几个月内出血风险增加了 33% (JAMA Netw Open doi:10.1001/jamanetworkopen.2024.3208)。法国的一项回顾性研究审查了 300 名符合标准的患者……