The mammalian hippocampus exhibits spontaneous sharp wave events (1–30 Hz) with an often-present superimposed fast ripple oscillation (120–220 Hz) to form a sharp wave ripple (SWR) complex. During slow-wave sleep or quiet restfulness, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during learned or imagined experiences. Additional cortical/subcortical areas exhibit SWR events that are coupled to hippocampal SWRs, and studies in mammals suggest that coupling may be critical for the consolidation and recall of specific memories. In the present study, we have examined juvenile male and female zebrafish and show that SWR events are intrinsically generated and maintained within the telencephalon and that their hippocampal homolog, the anterodorsolateral lobe (ADL), exhibits SW events with ~9% containing an embedded ripple (SWR). Single-cell calcium imaging coupled to local field potential recordings revealed that ~10% of active cells in the dorsal telencephalon participate in any given SW event. Furthermore, fluctuations in cholinergic tone modulate SW events consistent with mammalian studies. Moreover, the basolateral amygdala (BLA) homolog exhibits SW events with ~5% containing an embedded ripple. Computing the SW peak coincidence difference between the ADL and BLA showed bidirectional communication. Simultaneous coupling occurred more frequently within the same hemisphere, and in coupled events across hemispheres, the ADL more commonly preceded BLA. Together, these data suggest conserved mechanisms across species by which SW and SWR events are modulated, and memories may be transferred and consolidated through regional coupling.

哺乳动物海马体表现出自发的尖波事件（1-30 Hz），并经常存在叠加的快速波纹振荡（120-220 Hz），形成尖波波纹（SWR）复合体。在慢波睡眠或安静休息期间，SWR 是由在习得或想象的经历中最初激活的海马细胞组件的连续峰值引起的。其他皮质/皮质下区域表现出与海马 SWR 耦合的 SWR 事件，并且对哺乳动物的研究表明耦合可能对于特定记忆的巩固和回忆至关重要。在本研究中，我们检查了幼年雄性和雌性斑马鱼，结果表明 SWR 事件本质上是在端脑内产生和维持的，并且它们的海马同源物前背外侧叶 (ADL) 表现出 SW 事件，其中约 9% 包含嵌入式波纹（驻波比）。单细胞钙成像与局部场电位记录相结合表明，背侧端脑中约 10% 的活跃细胞参与任何给定的 SW 事件。此外，胆碱能张力的波动调节 SW 事件与哺乳动物研究一致。此外，基底外侧杏仁核 (BLA) 同源物表现出约 5% 包含嵌入波纹的 SW 事件。计算 ADL 和 BLA 之间的 SW 峰值重合差异显示双向通信。同时耦合在同一半球内发生的频率更高，而在跨半球的耦合事件中，ADL 更常见于 BLA 之前。总之，这些数据表明了跨物种的保守机制，通过这些机制调节 SW 和 SWR 事件，并且记忆可以通过区域耦合转移和巩固。