Background/Aims The Stickler syndrome is associated with functional changes in one of the COL2 (type 1, common), COL11 (type 2, uncommon) or COL9 (very rare) genes and causes early onset osteoarthritis. Previous studies have looked at the factors associated with response to pain management interventions in osteoarthritis, but none have done so in a Stickler syndrome cohort. We aimed to identify the factors associated with response to a pain management clinic in patients with osteoarthritis caused by Stickler syndrome. Methods All attendees completed the Brief Pain Inventory (BPI). Scores from 321 Stickler syndrome patients were gathered during each attendance of clinic. Repeat attenders were categorised into responders (BPI score improved on average by > 2 points) and non-responders (BPI score worsened on average by > 2 points). The responders (R) and non-responders (NR) cohorts were characterised and compared using variables including initial pain scores, pain management used, pain categories affected, time between visits, sex, age, genetic mutations, pain location and presence of joint replacements. Results 237/321 patients re-attended the clinic. 26/237 were Responders (R) and 30/237 were Non-responders (NR). All baseline BPI scores were statistically significantly higher in the R cohort, suggesting that the clinic provides greater benefit to those with greater levels of pain. Patients in the total cohort who started with high pain scores (7 or above) had an improvement in scores compared to those who started with low pain scores (3 or below), who had a worsening of scores (-1.158 vs 0.8194, p < 0.0001). Furthermore, there was a weak negative correlation between initial pain score and change in score (r2=0.136). Topical NSAIDs were more commonly used in the NR cohort (33.33% in NR vs 7.69% in R, p = 0.0248) whereas oral NSAIDs were more commonly used in the R cohort (6.67% in NR vs 30.77% in R, p = 0.0332). A final difference between the cohorts was the effect of the pain on the different interference scores. The NR cohort had a statistically significantly lower ‘relations’ score compared to the two most affected interference categories (p = 0.0113, p = 0.0214), whereas the R cohort had no statistically significant difference between the highest affected categories and ‘relations’, suggesting ‘relations’ were disproportionally unaffected in the NR cohort. The time between visits, sex, age, mutations, pain location and joint replacement presence were not statistically significantly different between the two cohorts. Conclusion Patients with high levels of pain benefited from the service. Factors associated with response were high initial pain scores, use of oral NSAIDs, and a ‘relations’ score which was not statistically significantly different to the other life quality categories. This information could be used in the future to help predict response to pain management interventions in Stickler syndrome. Disclosure R. Mudkavi: None. N. Shenker: None.

中文翻译：

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E052 描述与 Stickler 综合征患者疼痛管理反应相关的因素

背景/目的 Stickler 综合征与 COL2（1 型，常见）、COL11（2 型，罕见）或 COL9（非常罕见）基因之一的功能变化相关，并导致早发性骨关节炎。之前的研究已经研究了与骨关节炎疼痛管理干预措施反应相关的因素，但没有在斯蒂克勒综合征队列中进行过研究。我们的目的是确定与斯蒂克勒综合征引起的骨关节炎患者对疼痛管理诊所的反应相关的因素。方法 所有参与者均完成了简短疼痛量表 (BPI)。 321 名斯蒂克勒综合征患者每次就诊期间都会收集评分。重复参加者被分为响应者（BPI 得分平均提高了 2 分以上）和无响应者（BPI 得分平均恶化了 2 分以上）。使用初始疼痛评分、使用的疼痛管理、受影响的疼痛类别、就诊间隔时间、性别、年龄、基因突变、疼痛部位和是否进行关节置换等变量对有反应者 (R) 和无反应者 (NR) 队列进行表征和比较。结果 237/321 名患者再次就诊。 26/237 为有反应者 (R)，30/237 为无反应者 (NR)。 R 队列中的所有基线 BPI 评分在统计上均显着较高，这表明该诊所为疼痛程度较高的患者提供了更大的益处。整个队列中，与那些开始时疼痛评分较低（3 或以下）的患者相比，开始时疼痛评分较高（7 或以上）的患者评分有所改善，后者评分恶化（-1.158 vs 0.8194，p < ；0.0001）。此外，初始疼痛评分与评分变化之间存在弱负相关性（r2=0.136）。局部 NSAID 在 NR 队列中更常用（NR 中为 33.33%，R 中为 7.69%，p = 0.0248），而口服 NSAID 在 R 队列中更常用（NR 中为 6.67%，R 中为 30.77%，p = 0.0332 ）。队列之间的最后一个区别是疼痛对不同干扰分数的影响。与两个受影响最严重的干扰类别相比，NR 队列的“关系”得分在统计上显着较低（p = 0.0113，p = 0.0214），而 R 队列在受影响最大的类别和“关系”之间没有统计显着差异，这表明在 NR 队列中，“关系”并未受到不成比例的影响。两个队列之间的就诊时间、性别、年龄、突变、疼痛部位和关节置换情况没有统计学上的显着差异。结论 疼痛程度较高的患者从该服务中受益。与反应相关的因素包括较高的初始疼痛评分、口服非甾体抗炎药的使用以及与其他生活质量类别没有统计学显着差异的“关系”评分。这些信息将来可用于帮助预测斯蒂克勒综合征疼痛管理干预措施的反应。披露 R。穆德卡维：没有。 N.申克尔：没有。