Many types of tumor cells alter metabolic pathways to meet their energy and biosynthetic demands for proliferation or stress adaptation. In this issue of Cell, Kong et al. find that the glycolytic metabolite methylglyoxal causes cancer-associated mutant single-base substitution features by inducing BRCA2 proteolysis, leading to functional haploinsufficiency of BRCA2.

中文翻译：

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一种导致 BRCA2 单倍体不足的糖酵解代谢物

许多类型的肿瘤细胞改变代谢途径以满足其增殖或应激适应的能量和生物合成需求。在本期《细胞》中，Kong 等人。发现糖酵解代谢物甲基乙二醛通过诱导 BRCA2 蛋白水解而导致癌症相关突变单碱基取代特征，从而导致 BRCA2 功能性单倍体不足。