The bioaerogel microparticles have been recently developed for respiratory drug delivery and attract fast increasing interests. These highly porous microparticles have ultralow density and hence possess much reduced aerodynamic diameter, which favour them with greatly enhanced dispersibility and improved aerosolisation behaviour. The adjustable particle geometric dimensions by varying preparation methods and controlling operation parameters make it possible to fabricate bioaerogel microparticles with accurate sizes for efficient delivery to the targeted regions of respiratory tract (i.e. intranasal and pulmonary). Additionally, the technical process can provide bioaerogel microparticles with the opportunities of accommodating polar, weak polar and non-polar drugs at sufficient amount to satisfy clinical needs, and the adsorbed drugs are primarily in the amorphous form that potentially can facilitate drug dissolution and improve bioavailability. Finally, the nature of biopolymers can further offer additional advantageous characteristics of improved mucoadhesion, sustained drug release and subsequently elongated time for continuous treatment on-site. These fascinating features strongly support bioaerogel microparticles to become a novel platform for effective delivery of a wide range of drugs to the targeted respiratory regions, with increased drug residence time on-site, sustained drug release, constant treatment for local and systemic diseases and anticipated better-quality of therapeutic effects.

中文翻译：

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用于呼吸道药物输送的颗粒生物气凝胶


生物气凝胶微粒最近被开发用于呼吸药物输送，并引起了快速增长的兴趣。这些高度多孔的微粒具有超低密度，因此具有大大减小的空气动力学直径，这有利于它们大大增强的分散性和改善的气雾化行为。通过改变制备方法和控制操作参数可调节颗粒几何尺寸，使得可以制造具有精确尺寸的生物气凝胶微粒，以有效递送至呼吸道目标区域（即鼻内和肺部）。此外，该技术工艺可以为生物气凝胶微粒提供容纳足够量的极性、弱极性和非极性药物的机会，以满足临床需要，并且吸附的药物主要呈无定形形式，有可能促进药物溶出并提高生物利用度。最后，生物聚合物的性质可以进一步提供额外的有利特性，例如改善粘膜粘附、持续药物释放以及随后延长的现场连续治疗时间。这些令人着迷的特性有力地支持了生物气凝胶微粒成为一种新的平台，可以将多种药物有效输送到目标呼吸区域，增加药物在现场的停留时间，持续释放药物，持续治疗局部和全身疾病，并有望获得更好的效果。 -治疗效果的质量。