We read with interest the population-based cohort studies by Abrahami et al on proton pump inhibitors (PPI) and the risk of gastric and colon cancers.1 2 PPI are used at all levels of healthcare and across different subspecialties for various indications.3 4 A recent systematic review on the global trends and practices of PPI recognised 28 million PPI users from 23 countries, suggesting that 23.4% of the adults were using PPI.5 Inappropriate use of PPI appears to be frequent, although there is a lack of compiled information on the prevalence of inappropriate overuse of PPI. Hence, we conducted a systematic review and meta-analysis on the inappropriate overuse of PPI globally. The details of the methodology are described in the online supplemental file. The literature was searched from inception until 19 July 2023 (PubMed, Embase and Scopus) for studies that reported on the inappropriate overuse of PPI. Two investigators independently performed each step, from screening to study selection to data extraction and quality assessment. The pooled rates were calculated using a random intercept logistic regression model. The Preferred Reporting …

中文翻译：

---

全球临床实践中质子泵抑制剂的不当使用：系统评价和荟萃分析

我们饶有兴趣地阅读了 Abrahami 等人关于质子泵抑制剂 (PPI) 以及胃癌和结肠癌风险的基于人群的队列研究。1 2 PPI 用于各级医疗保健和不同亚专业的各种适应症。3 4最近一项关于 PPI 全球趋势和实践的系统回顾发现，来自 23 个国家的 2800 万 PPI 用户表明，23.4% 的成年人正在使用 PPI。5 尽管缺乏汇总信息，但 PPI 的不当使用似乎很常见不当过度使用 PPI 的普遍性。因此，我们对全球范围内 PPI 的不当过度使用进行了系统回顾和荟萃分析。在线补充文件中描述了该方法的详细信息。检索了从开始到 2023 年 7 月 19 日期间的文献（PubMed、Embase 和 Scopus），寻找报告不恰当过度使用 PPI 的研究。两名研究人员独立执行每个步骤，从筛选到研究选择，再到数据提取和质量评估。使用随机截距逻辑回归模型计算汇总率。首选报告...