Background Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project—an international consortium of epidemiological studies on GC. Methods Data from five case–control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose–response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial. Results The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63–0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57–0.91), intestinal-type (OR: 0.75; 95% CI: 0.56–0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44–0.96). The dose–response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02–0.41) and slowly increased for higher intakes. Conclusions The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.

中文翻译：

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铜的膳食摄入量与胃癌：胃癌汇集 (StoP) 项目中的汇总分析

背景 目前尚缺乏膳食铜摄入量与胃癌 (GC) 之间潜在关联的证据。因此，我们旨在评估胃癌汇集 (StoP) 项目（胃癌流行病学研究国际联盟）内的这种关联。方法 纳入了 StoP 项目内五项病例对照研究的数据（2448 例病例，4350 名对照）。我们使用多变量混合效应逻辑回归模型估计了膳食铜摄入量与 GC 之间关联的调整优势比 (OR) 和 95% CI。我们还使用分数多项式逻辑混合效应模型对铜摄入量和 GC 之间的剂量反应关系进行了建模。结果 铜摄入量最高四分位与最低四分位相比，OR 为 0.78（95% CI：0.63–0.95；趋势 P = 0.013）。非贲门型（OR：0.72；95% CI：0.57-0.91）、肠型（OR：0.75；95% CI：0.56-0.99）和其他组织学类型GC（OR：0.65；95% CI：0.56-0.99）的结果相似。 95% CI：0.44–0.96）。剂量反应分析显示，适度摄入量（<1 mg/天）的 OR 急剧下降，随后在 ≤ 3 mg/天时保持稳定（OR：0.09；95% CI：0.02-0.41），并在 ≤ 3 mg/天时缓慢增加。更高的摄入量。结论 我们的大型研究结果表明，铜的摄入量可能与 GC 呈负相关，尽管还需要前瞻性研究的证实。