Tactile sensing requires integrated detection platforms with distributed and highly sensitive haptic sensing capabilities along with biocompatibility, aiming to replicate the physiological functions of the human skin and empower industrial robotic and prosthetic wearers to detect tactile information. In this regard, short peptide-based self-assembled hydrogels show promising potential to act as bioinspired supramolecular substrates for developing tactile sensors showing biocompatibility and biodegradability. However, the intrinsic difficulty to modulate the mechanical properties severely restricts their extensive employment. Herein, by controlling the self-assembly of 9-fluorenylmethoxycarbonyl-modifid diphenylalanine (Fmoc-FF) through introduction of polyethylene glycol diacrylate (PEGDA), wider nanoribbons are achieved by untwisting from well-established thinner nanofibers, and the mechanical properties of the supramolecular hydrogels can be enhanced 10-fold, supplying bioinspired supramolecular encapsulating substrate for tactile sensing. Furthermore, by doping with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and 9-fluorenylmethoxycarbonyl-modifid 3,4-dihydroxy-l-phenylalanine (Fmoc-DOPA), the Fmoc-FF self-assembled hydrogels can be engineered to be conductive and adhesive, providing bioinspired sensing units and adhesive layer for tactile sensing applications. Therefore, the integration of these modules results in peptide hydrogelation-based tactile sensors, showing high sensitivity and sustainable responses with intrinsic biocompatibility and biodegradability. The findings establish the feasibility of developing programmable peptide self-assembly with adjustable features for tactile sensing applications.

中文翻译：

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具有可编程触觉传感特性的仿生柔性水凝胶

触觉传感需要具有分布式、高灵敏度触觉传感功能以及生物相容性的集成检测平台，旨在复制人类皮肤的生理功能，并使工业机器人和假肢佩戴者能够检测触觉信息。在这方面，基于短肽的自组装水凝胶显示出作为仿生超分子基底的巨大潜力，可用于开发具有生物相容性和生物可降解性的触觉传感器。然而，调节机械性能的内在困难严重限制了它们的广泛应用。在此，通过引入聚乙二醇二丙烯酸酯（PEGDA）来控制9-芴基甲氧基羰基修饰的二苯丙氨酸（Fmoc-FF）的自组装，通过从成熟的更薄的纳米纤维中解开来获得更宽的纳米带，并且超分子的机械性能水凝胶可以增强 10 倍，为触觉传感提供仿生超分子封装基质。此外，通过掺杂聚(3,4-乙撑二氧噻吩):聚(苯乙烯磺酸)(PEDOT:PSS)和9-芴基甲氧基羰基-改性3,4-二羟基-1-苯丙氨酸(Fmoc-DOPA)，Fmoc-FF自身-组装的水凝胶可以设计为具有导电性和粘合性，为触觉传感应用提供仿生传感单元和粘合层。因此，这些模块的集成产生了基于肽水凝胶的触觉传感器，显示出高灵敏度和可持续响应以及内在的生物相容性和生物可降解性。研究结果证实了开发具有可调功能的用于触觉传感应用的可编程肽自组装的可行性。