I-131 is a radioisotope widely used in nuclear medicine for the treatment of pathologies such as thyroid cancer or hyperthyroidism. When I-131 is ingested, it rapidly accumulates in the thyroid gland, emitting radiation that affects the targeted thyroid tissue while also impacting other organs. To ensure patients receive the appropriate dose for desired therapeutic outcomes while minimizing the risk of adverse effects, accurate estimations of absorbed doses after the treatment is crucial. This study focuses on evaluating organ doses following I-131 pill administration. It leverages the recent High-Resolution Anthropomorphic Computational Phantom distributed by the International Commission on Radiological Protection (ICRP), known as the Mesh Type Reference Computational Phantom. Additionally, a biokinetic analysis of iodine is conducted using a developed tool based on the ICRP compartment model for oral iodine administration. Furthermore, Monte Carlo simulation techniques employing the MCNP6.2 code have been used to examine the radiation transport within the phantom at various time points. Consequently, the study provides dose data for each affected organ throughout the treatment, demonstrating the suitability of this simulation methodology for conducting dosimetric investigations in thyroid treatment.

中文翻译：

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通过蒙特卡罗模拟确定放射性碘甲状腺治疗中的器官剂量

I-131 是一种放射性同位素，广泛用于核医学中，用于治疗甲状腺癌或甲状腺功能亢进等疾病。当 I-131 被摄入后，它会迅速在甲状腺中积聚，发出辐射影响目标甲状腺组织，同时也会影响其他器官。为了确保患者接受适当的剂量以获得所需的治疗结果，同时最大限度地降低不良反应的风险，准确估计治疗后的吸收剂量至关重要。本研究的重点是评估服用 I-131 药丸后的器官剂量。它利用了国际放射防护委员会 (ICRP) 最近发布的高分辨率拟人计算模型，称为网格类型参考计算模型。此外，还使用基于口服碘给药 ICRP 室模型的开发工具进行了碘的生物动力学分析。此外，采用 MCNP6.2 代码的蒙特卡罗模拟技术已用于检查不同时间点体模内的辐射传输。因此，该研究提供了整个治疗过程中每个受影响器官的剂量数据，证明了这种模拟方法适用于在甲状腺治疗中进行剂量测定研究。