Aims/hypothesis

The aim of this study was to examine the dose–response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health.

Methods

We conducted an individual participant harmonised meta-analysis of 12,095 adults (mean ± SD age 54.5±9.6 years; female participants 54.8%) from six cohorts with thigh-worn accelerometry data from the Prospective Physical Activity, Sitting and Sleep (ProPASS) Consortium. Associations of daily walking, stair climbing, running, standing and sitting time with a composite cardiometabolic health score (based on standardised z scores) and individual cardiometabolic markers (BMI, waist circumference, triglycerides, HDL-cholesterol, HbA_1c and total cholesterol) were examined cross-sectionally using generalised linear modelling and cubic splines.

Results

We observed more favourable composite cardiometabolic health (i.e. z score <0) with approximately 64 min/day walking (z score [95% CI] −0.14 [−0.25, −0.02]) and 5 min/day stair climbing (−0.14 [−0.24, −0.03]). We observed an equivalent magnitude of association at 2.6 h/day standing. Any amount of running was associated with better composite cardiometabolic health. We did not observe an upper limit to the magnitude of the dose–response associations for any activity type or standing. There was an inverse dose–response association between sitting time and composite cardiometabolic health that became markedly less favourable when daily durations exceeded 12.1 h/day. Associations for sitting time were no longer significant after excluding participants with prevalent CVD or medication use. The dose–response pattern was generally consistent between activity and posture types and individual cardiometabolic health markers.

Conclusions/interpretation

In this first activity type-specific analysis of device-based physical activity, ~64 min/day of walking and ~5.0 min/day of stair climbing were associated with a favourable cardiometabolic risk profile. The deleterious associations of sitting time were fully attenuated after exclusion of participants with prevalent CVD and medication use. Our findings on cardiometabolic health and durations of different activities of daily living and posture may guide future interventions involving lifestyle modification.

Graphical Abstract

中文翻译：

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设备测量的体力活动类型和姿势与心脏代谢健康指标的关系：来自前瞻性体力活动、坐姿和睡眠联盟的汇总剂量-反应关联

目标/假设

本研究的目的是检查设备测量的身体活动类型和姿势（坐和站立时间）与心脏代谢健康的剂量反应关联。

方法

我们对来自 6 个队列的 12,095 名成年人（平均 ± SD 年龄 54.5±9.6 岁；女性参与者 54.8%）进行了个体参与者的协调荟萃分析，这些数据来自前瞻性身体活动、坐姿和睡眠 (ProPASS) 联盟。每日步行、爬楼梯、跑步、站立和坐着时间与综合心脏代谢健康评分（基于标准化z评分）和个体心脏代谢标志物（BMI、腰围、甘油三酯、HDL-胆固醇、HbA _1c和总胆固醇）之间的关联使用广义线性模型和三次样条进行横截面检查。

结果

我们观察到每天步行约 64 分钟（z得分 [95% CI] −0.14 [−0.25, −0.02 ]）和每天 5 分钟爬楼梯（−0.14 [ -0.24，-0.03]）。我们在每天站立 2.6 小时时观察到了同等程度的关联。任何数量的跑步都与更好的综合心脏代谢健康相关。我们没有观察到任何活动类型或站立的剂量反应关联程度的上限。静坐时间与综合心脏代谢健康之间存在反向剂量反应关系，当每日持续时间超过 12.1 小时时，这种关系明显变得不太有利。排除患有流行性心血管疾病或药物使用的参与者后，静坐时间的相关性不再显着。活动和姿势类型以及个体心脏代谢健康标志物之间的剂量反应模式通常是一致的。

结论/解释

在对基于设备的身体活动进行的第一项特定活动类型分析中，每天约 64 分钟的步行和每天约 5.0 分钟的爬楼梯与良好的心脏代谢风险状况相关。在排除患有普遍的心血管疾病和药物使用的参与者后，久坐时间的有害关联被完全减弱。我们关于心脏代谢健康以及不同日常生活活动和姿势的持续时间的研究结果可能会指导未来涉及生活方式改变的干预措施。

图形概要