Aims/hypothesis

The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.

Methods

The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother–child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.

Results

There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.

Conclusions/interpretation

Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.

Graphical Abstract

中文翻译：

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在两个大型斯堪的纳维亚妊娠队列中，怀孕期间长链 n-3 脂肪酸的摄入量与后代患 1 型糖尿病的风险之间没有关联

目标/假设

本研究的目的是调查怀孕期间较高的海洋n -3 脂肪酸饮食摄入量是否与儿童患 1 型糖尿病的风险较低相关。

方法

丹麦国家出生队列 (DNBC) 和挪威母亲、父亲和儿童队列研究 (MoBa) 总共纳入了 153,843 对母婴，前瞻性收集了怀孕期间从经过验证的食物中摄入二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 的数据频率问卷。儿童 1 型糖尿病诊断 ( n = 634) 由国家糖尿病登记处确定。

结果

妊娠期间 EPA 和 DHA 摄入量总和与后代 1 型糖尿病风险之间没有关联（每克/天摄入量的汇总 HR：1.00，95% CI 0.88，1.14），MoBa 和民主党全国委员会。稳健性分析给出了非常相似的结果。

结论/解释

不应优先考虑在怀孕期间启动 EPA 和 DHA 试验来预防后代 1 型糖尿病。

图形概要