Due to the relatively low efficiency of magnetic hyperthermia and photothermal conversion, it is rather challenging for magneto-photothermal nanoagents to be used as an effective treatment during tumor hyperthermal therapy. The advancement of magnetic nanoparticles exhibiting a vortex-domain structure holds great promise as a viable strategy to enhance the application performance of conventional magnetic nanoparticles while retaining their inherent biocompatibility. Here, we report the development of Mn_0.5Zn_0.5Fe₂O₄ nanoflowers with ellipsoidal magnetic cores, and show them as effective nanoagents for magneto-photothermal synergistic therapy. Comparative studies were conducted on the heating performance of anisometric Mn_0.5Zn_0.5Fe₂O₄ (MZF) nanoparticles, including nanocubes (MZF–C), hollow spheres (MZF–HS), nanoflowers consisting of ellipsoidal magnetic cores (MZF–NFE), and nanoflowers consisting of needle-like magnetic cores (MZF–NFN). MZF–NFE exhibits an intrinsic loss parameter (ILP) of up to 15.3 N h m² kg⁻¹, which is better than that of commercial equivalents. Micromagnetic simulations reveal the magnetization configurations and reversal characteristics of the various MZF shapes. Additionally, all nanostructures displayed a considerable photothermal conversion efficiency rate of more than 18%. Our results demonstrated that by combining the dual exposure of MHT and PTT for hyperthermia treatments induced by MZF–NFE, BT549, MCF-7, and 4T1 cell viability can be significantly decreased by ∼95.7% in vitro.

中文翻译：

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近红外和磁双响应多核磁涡流纳米花促进磁光热癌症治疗

由于磁热疗和光热转换的效率相对较低，磁光热纳米制剂在肿瘤热疗过程中作为有效的治疗方法具有相当的挑战性。表现出涡旋域结构的磁性纳米粒子的进步作为一种可行的策略具有巨大的前景，可以增强传统磁性纳米粒子的应用性能，同时保留其固有的生物相容性。在这里，我们报告了具有椭圆形磁芯的Mn _0.5 Zn _0.5 Fe ₂ O ₄纳米花的开发，并展示了它们作为磁光热协同治疗的有效纳米药剂。对不等轴Mn _0.5 Zn _0.5 Fe ₂ O ₄ (MZF)纳米颗粒的加热性能进行了比较研究，包括纳米立方体(MZF–C)、空心球(MZF–HS)、椭圆体磁芯组成的纳米花(MZF–NFE) ，以及由针状磁芯组成的纳米花（MZF-NFN）。 MZF-NFE 的固有损耗参数（ILP）高达 15.3 N hm ² kg ⁻¹，优于商业同类产品。微磁模拟揭示了各种 MZF 形状的磁化配置和反转特性。此外，所有纳米结构都表现出超过18%的相当大的光热转换效率。我们的结果表明，通过结合 MHT 和 PTT 的双重暴露进行 MZF-NFE、BT549、MCF-7 和 4T1 诱导的热疗，体外细胞活力可显着降低约 95.7% 。