Reported herein is the use of a ligand to tune palladium-catalyzed intramolecular Heck gem-difluorovinylation and carboxylation with alkene-tethered aryl halides, which provides an efficient avenue for building indolo[2,1-a]isoquinoline skeletons. Sodium difluorochloroacetate (ClCF₂COONa) acts as both a difluorocarbene (:CF₂) and carboxyl source. A broad substrate scope, diversified transformations and gram scale-up reaction meant that the products had potential for their own further applications.

中文翻译：

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从偕二氟乙烯基化转变为羧化：配体钯催化的烯烃束缚芳基卤化物与二氟氯乙酸钠的 Heck 环化

本文报道了使用配体来调节钯催化的Heck gem-二氟乙烯基化和与烯烃束缚的芳基卤化物的羧化，这为构建吲哚并[2,1- a ]异喹啉骨架提供了有效的途径。二氟氯乙酸钠 (ClCF ₂ COONa) 既充当二氟卡宾 (:CF ₂ ) 又充当羧基源。广泛的底物范围、多样化的转化和克级放大反应意味着该产品具有进一步应用的潜力。