To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). In 107 individuals one-year post-ACLR, adiposity was assessed globally (body mass index), centrally (waist circumference), and peripherally (knee subcutaneous adipose tissue thickness) from magnetic resonance imaging (MRI). Tibiofemoral and patellofemoral cartilage lesions were assessed from knee MRIs at 1- and 5-years post-ACLR. Poisson regression evaluated the relation of adiposity with prevalent and worsening tibiofemoral and patellofemoral cartilage lesions adjusting for age, sex, and activity level. The prevalence ratios of adiposity with tibiofemoral (presence in 49%) and patellofemoral (44%) cartilage lesions ranged from 0.99 to 1.03. Adiposity was more strongly associated with longitudinal changes in tibiofemoral (worsening in 21%) and patellofemoral (44%) cartilage lesions. One-unit increase in global (kg/m), central (cm), and peripheral (mm) adiposity was associated with a higher risk of worsening tibiofemoral cartilage lesions by 17% (risk ratios [95% confidence interval (CI)]: 1.17 [1.09 to 1.23]), 5% (1.05 [1.02 to 1.08]), and 9% (1.09 [1.03 to 1.16]), and patellofemoral cartilage lesions by 5% (1.05 [1.00 to 1.12]), 2% (1.02 [1.00 to 1.04]) and 2% (1.02 [1.00 to 1.04]), respectively. Greater adiposity was a risk factor for worsening cartilage lesions up to 5 years post-ACLR. Clinical interventions aimed at mitigating excess adiposity may be beneficial in preventive approaches for early post-traumatic osteoarthritis.

中文翻译：

---

ACL 重建后的肥胖和软骨损伤


确定全身、中央或外周肥胖是否与前交叉韧带重建 (ACLR) 后普遍且恶化的软骨损伤相关。 ACLR 术后一年后，通过磁共振成像 (MRI) 对 107 名个体进行了整体（体重指数）、中央（腰围）和外周（膝盖皮下脂肪组织厚度）的肥胖评估。在 ACLR 术后 1 年和 5 年，通过膝关节 MRI 评估胫股骨和髌股软骨损伤。泊松回归评估了肥胖与普遍和恶化的胫股和髌股软骨病变的关系，并根据年龄、性别和活动水平进行了调整。肥胖伴胫股软骨损伤（49%）和髌股软骨损伤（44%）的患病率范围为 0.99 至 1.03。肥胖与胫股骨（21% 恶化）和髌股骨（44%）软骨病变的纵向变化密切相关。全身 (kg/m)、中央 (cm) 和外周 (mm) 肥胖增加 1 个单位与胫股软骨病变恶化的风险增加 17% 相关（风险比 [95% 置信区间 (CI)]： 1.17 [1.09 至 1.23]）、5%（1.05 [1.02 至 1.08]）和 9%（1.09 [1.03 至 1.16]），髌股软骨病变 5%（1.05 [1.00 至 1.12]）、2%（分别为 1.02 [1.00 至 1.04]）和 2%（1.02 [1.00 至 1.04]）。过度肥胖是 ACLR 术后 5 年内软骨损伤恶化的危险因素。旨在减轻过度肥胖的临床干预措施可能有益于早期创伤后骨关节炎的预防方法。