Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection,Emerging Microbes & Infections

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Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2024-05-20 , DOI: 10.1080/22221751.2024.2350168
Yannik Vollmuth _{1,

2,

3} , Nicola Jungbäck ₁ , Tatiana Mögele ₁ , Friederike Schmidt-Graf ₄ , Silke Wunderlich ₄ , Mareike Schimmel ₅ , Camilla Rothe ₆ , Leonhard Stark ₂ , Jürgen Schlegel _{1,

2} , Georg Rieder ₇ , Thomas Richter ₈ , Tina Schaller ₁ , Dennis Tappe ₉ , Bruno Märkl ₁ , Kaspar Matiasek ₁₀ , Friederike Liesche-Starnecker ₁

Affiliation

Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany
Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany
Department of Pediatrics, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University Munich, Munich, Germany
Department of Neurology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany
Department of Pediatrics and Adolescent Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany
Division of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-University Munich, Munich, Germany
Department of Neurology, InnKlinikum, Altötting, Germany
Clinic of Pathology, Pathology Rosenheim, Rosenheim, Germany
National Reference Laboratory for Bornaviruses, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Section of Clinical and Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University Munich, Munich, Germany

Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for e...

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