Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mechanical distension and macrophage interrogation. These results from preclinical in vitro testing show the potential of this approach for testing and improving materials before their introduction into the clinic.

中文翻译：

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加强临床前测试以提高手术网片的安全性

对聚丙烯网的炎症和纤维化反应导致一些国家取消了这种治疗女性压力性尿失禁和盆腔器官脱垂的做法。人们敦促改进材料测试。我们报告聚丙烯网对重复机械扩张和巨噬细胞询问的反应较差。临床前体外测试的这些结果表明，这种方法在材料引入临床之前测试和改进材料的潜力。