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Update on Hemodialysis-Induced Multiorgan Ischemia: Brains and Beyond
Journal of the American Society of Nephrology ( IF 13.6 ) Pub Date : 2024-01-26 , DOI: 10.1681/asn.0000000000000299
Christopher W. McIntyre 1
Affiliation  

ion, abnormal perfusion to critical organs (heart, brain, liver, and kidney), and damage to vulnerable vascular beds. Recurrent conventional hemodialysis exposes patients to multiple episodes of circulatory stress, exacerbating and being aggravated by microvascular endothelial dysfunction. This promulgates progressive injury that leads to irreversible multiorgan injury and the well-documented higher incidence of cardiovascular disease and premature death. This review aims to examine the underlying pathophysiology of hemodialysis-related vascular injury and consider a range of therapeutic approaches to improving outcomes set within this evolved rubric.‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬...

中文翻译:

血液透析引起的多器官缺血的最新进展:大脑及其他领域

离子、关键器官(心脏、大脑、肝脏和肾脏)的异常灌注以及对脆弱血管床的损害。反复进行的传统血液透析使患者面临多次循环应激,从而加剧微血管内皮功能障碍。这会导致进行性损伤,导致不可逆的多器官损伤,以及有据可查的心血管疾病和过早死亡的高发病率。本综述旨在研究血液透析相关血管损伤的潜在病理生理学,并考虑一系列治疗方法来改善这一演变的标题中设定的结果。 ‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬ ‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬ ...
更新日期:2024-01-26
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