Chronic skin wounds, especially infected ones, pose a significant clinical challenge due to their increasing incidence and poor outcomes. The deteriorative microenvironment in such wounds, characterized by reduced extracellular matrix, impaired angiogenesis, insufficient neurogenesis, and persistent bacterial infection, has prompted the exploration of novel therapeutic strategies. In this study, we developed an injectable multifunctional hydrogel (GEL/BG@Cu + Mg) incorporating Gelatin-Tannic acid/ N-hydroxysuccinimide functionalized polyethylene glycol and Bioactive glass doped with copper and magnesium ions to accelerate the healing of infected wounds. The GEL/BG@Cu + Mg hydrogel composite demonstrates good biocompatibility, degradability, and rapid formation of a protective barrier to stop bleeding. Synergistic bactericidal effects are achieved through the photothermal properties of BG@Cu + Mg and sustained copper ions release, with the latter further promoting angiogenesis. Furthermore, the hydrogel enhances neurogenesis by stimulating axons and Schwann cells in the wound bed through the beneficial effects of magnesium ions. Our results demonstrate that the designed novel multifunctional hydrogel holds tremendous promise for treating infected wounds and allowing regenerative neurogenesis at the wound site, which provides a viable alternative for further improving clinical outcomes.

中文翻译：

---

精准愈合：多功能水凝胶生物活性玻璃敷料可促进感染伤口恢复并增强创面神经发生


慢性皮肤伤口，尤其是感染性皮肤伤口，由于其发病率不断增加且预后不良，构成了重大的临床挑战。此类伤口中恶化的微环境，其特征是细胞外基质减少、血管生成受损、神经发生不足​​和持续的细菌感染，促使人们探索新的治疗策略。在这项研究中，我们开发了一种可注射的多功能水凝胶（GEL/BG@Cu + Mg），其中包含明胶-单宁酸/N-羟基琥珀酰亚胺功能化聚乙二醇和掺杂铜和镁离子的生物活性玻璃，以加速感染伤口的愈合。 GEL/BG@Cu + Mg 水凝胶复合材料表现出良好的生物相容性、可降解性，并能快速形成止血保护屏障。通过BG@Cu + Mg的光热特性和持续的铜离子释放来实现协同杀菌作用，后者进一步促进血管生成。此外，水凝胶通过镁离子的有益作用刺激创面床中的轴突和施万细胞，从而增强神经发生。我们的结果表明，设计的新型多功能水凝胶在治疗感染伤口和允许伤口部位再生神经发生方面具有巨大前景，这为进一步改善临床结果提供了可行的替代方案。