How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.¹ utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.

中文翻译：

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揭开核RNA稳态之谜

核 RNA 稳态如何影响细胞功能仍然难以捉摸。在本期《细胞干细胞》中，Han 等人。¹利用针对 EXOSC2 的可控蛋白质降解系统扰乱小鼠多能胚胎干细胞中的 RNA 稳态，揭示了其在协调细胞健康的关键核事件中的重要作用。