The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al.¹ demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response.

中文翻译：

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eIF4G 作为热休克 mRNA 翻译的开关

热休克反应对于细胞存活至关重要。在本期《分子细胞》中，Desroches Altamirano 等人。图¹证明翻译起始因子eIF4G中温度诱导的构象变化是热激反应期间调节翻译的关键机制。