Childhood sexual abuse (CSA) is a severe global problem associated with alcohol use disorder (AUD). Previous studies have confirmed this relationship; however, there is a lack of research on the disease burden of AUD attributable to CSA. To analyze global spatiotemporal trends and differences in the disease burden of AUD attributable to CSA and its relationship with age, sex, and the sociodemographic index (SDI). Data from the Global Burden of Disease 2019 Public Database. Summary exposure value (SEV) was used to evaluate CSA. Disability-adjusted life year (DALY), years lived with disability (YLD), years of life lost (YLL), and their annual rates of change were used to evaluate disease burden. Cluster analysis based on Ward's method was used to examine the global burden associated with age, sex, and SDI. A 95 % uncertainty intervals (UI), excluding 0, was considered statistically significant. In 2019, 1.63 million (95 % UI 0.23–3.90 million) DALYs of AUD were caused by CSA and the age-standardized rates (ASRs) of DALY was 19.77 (95 % UI 2.78–47.46) globally. Annual rates of change in DALY of people over 65 years of age increased from 1990 to 2019 in all regions except the High-middle SDI regions. The ASRs of DALY of females in High SDI regions, were always at a much higher level than other SDI regions, and showed an upward trend from 1990 to 2019 (DALY 1990: 20.38 [95 % UI 2.87–47.77], 2019: 23.61 [95 % UI 3.55–54.94]). Substantial geographical differences were observed in the burden of AUD attributable to CSA. The level of CSA exposure was inconsistent with the related burden of AUD in different regions according to the sociodemographic index. The burden of disease increased in the elderly population and in females in high sociodemographic index regions.

中文翻译：

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按性别、年龄和社会人口指数划分的儿童性虐待造成的酒精使用障碍负担的全球趋势和差异：2019 年全球疾病负担研究的结果

儿童性虐待（CSA）是一个与酒精使用障碍（AUD）相关的严重全球问题。之前的研究已经证实了这种关系；然而，目前缺乏对 CSA 造成的 AUD 疾病负担的研究。分析 CSA 导致的 AUD 疾病负担的全球时空趋势和差异及其与年龄、性别和社会人口指数 (SDI) 的关系。数据来自 2019 年全球疾病负担公共数据库。总结暴露值（SEV）用于评估CSA。伤残调整生命年（DALY）、伤残生存年数（YLD）、生命损失年数（YLL）及其年变化率用于评估疾病负担。基于 Ward 方法的聚类分析用于检查与年龄、性别和 SDI 相关的全球负担。 95% 的不确定性区间 (UI)（不包括 0）被认为具有统计显着性。 2019 年，CS​​A 造成 163 万澳元（95% UI 0.23-390 万）DALY，全球 DALY 年龄标准化率为 19.77（95% UI 2.78-47.46）。从 1990 年到 2019 年，除中高 SDI 地区外，所有地区 65 岁以上人口 DALY 的年变化率均有所增加。高 SDI 地区女性 DALY 的 ASR 始终远高于其他 SDI 地区，并且从 1990 年至 2019 年呈上升趋势（DALY 1990：20.38 [95 % UI 2.87–47.77]，2019 年：23.61 [ 95% UI 3.55–54.94]）。 CSA 的澳元负担存在显着的地域差异。根据社会人口统计指数，不同地区的CSA暴露水平与AUD的相关负担不一致。在高社会人口指数地区，老年人口和女性的疾病负担增加。