A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.

中文翻译：

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脑-肌肉通讯通过维持日常生理机能来防止肌肉衰老

分子时钟网络对于日常生理和维持机体健康至关重要。我们研究了组织内时钟网络在肌肉组织维护中的相互作用和重要性。在表现出过早衰老的心律失常小鼠中，我们创建了一个涉及中枢时钟和外周（肌肉）时钟的基本时钟模块。重建大脑-肌肉时钟网络足以维持基本的日常稳态功能并防止肌肉过早老化。然而，实现整个肌肉生理学需要其他外周时钟的贡献。从机制上讲，肌肉外周时钟充当看门人的作用，选择性地抑制来自中央时钟的有害信号，同时整合重要的肌肉稳态功能。我们的研究揭示了日常肌肉功能中中枢和外周时钟之间的相互作用，并强调了饮食模式对这些相互作用的影响。