Standardized mouse inbred strains have been central to biomedical research for decades, ensuring experimental reproducibility across laboratories and experiments. However, the lack of genetic diversity within and between inbred mouse strain is an important limitation. A study in Plos Genetics reports the development of a new set of 11 inbred strains derived from wild-caught Mus musculus domesticus, sampled from five environmentally distinct locations across North and South America. These ‘Nachman strains’, which harbor millions of genetic variants absent from current laboratory mouse models, showed extensive phenotypic diversity when tested for several metabolic, neurobehavioral, physiological, morphological and biochemical traits. This new wild-derived inbred strain panel complements existing diverse mouse panels, such as the BXD, the collaborative cross or the hybrid mouse diversity panel, and contributes to expand the range of trait variation observed in laboratory mice.

Original reference: Dumont, B. L. et al. PLoS Genet. 20, e1011228 (2024)

几十年来，标准化小鼠近交系一直是生物医学研究的核心，确保了实验室和实验的实验可重复性。然而，近交系小鼠品系内部和之间缺乏遗传多样性是一个重要的限制。《Plos Genetics》的一项研究报告称，从野生捕获的小家鼠（Mus musculus Domesticus）中开发出了一组新的 11 种近交菌株，这些菌株是从北美和南美五个环境不同的地点取样的。这些“纳赫曼品系”含有数百万个当前实验室小鼠模型中不存在的遗传变异，在对多种代谢、神经行为、生理、形态和生化特征进行测试时，显示出广泛的表型多样性。这种新的野生自交系组补充了现有的多样化小鼠组，例如 BXD、协作杂交或杂种小鼠多样性组，并有助于扩大在实验室小鼠中观察到的性状变异范围。

原始参考文献： Dumont, BL 等人。公共科学图书馆基因网。20、e1011228 (2024)