End-stage heart disease is associated with severe tissue loss and fat wasting, with obesity being a risk factor. However, obese patients have a higher likelihood of surviving heart failure compared to normal-weight individuals. While the circadian rhythm is closely linked to lipid metabolism, the relationship between the circadian rhythm, fat loss and heart failure remains unknown. A study in Scientific Reports shows that the disruption of rats’ circadian clock promotes fat loss associated with heart failure. Injecting rats with monocrotaline induced pulmonary hypertension, leading to heart failure. Animals in the heart failure group with a normal circadian rhythm showed increased expression of the biological clock central feedback loop protein REV-ERBα in adipose tissue compared to control rats injected with vehicle solution. All heart failure groups showed significant fat loss after eight weeks of treatment. However, reversing the light cycle or inhibiting the circadian clock protein brain and muscle Arnt-like protein 1 (BMAL1) via lentiviral methods led to more severe fat loss. Targeting the BMAL1/REV-ERBα circadian rhythmic loop can serve as a future therapy for fat expenditure in heart failure.

Original reference: Ma, D. et al. Sci. Rep. 14, 8128 (2024)

终末期心脏病与严重的组织损失和脂肪消耗有关，其中肥胖是一个危险因素。然而，与正常体重的人相比，肥胖患者心力衰竭存活的可能性更高。虽然昼夜节律与脂质代谢密切相关，但昼夜节律、脂肪减少和心力衰竭之间的关系仍不清楚。《科学报告》中的一项研究表明，大鼠生物钟的破坏会促进与心力衰竭相关的脂肪减少。给老鼠注射野百合碱会引起肺动脉高压，导致心力衰竭。与注射载体溶液的对照大鼠相比，昼夜节律正常的心力衰竭组动物的脂肪组织中生物钟中央反馈环蛋白 REV-ERBα 的表达增加。所有心力衰竭组在八周治疗后均显示出显着的脂肪减少。然而，通过慢病毒方法逆转光周期或抑制生物钟蛋白大脑和肌肉 Arnt 样蛋白 1 (BMAL1) 会导致更严重的脂肪减少。靶向 BMAL1/REV-ERBα 昼夜节律环可以作为心力衰竭脂肪消耗的未来治疗方法。

原始参考： Ma, D. et al.科学。代表。14、8128 (2024)