Acute-on-chronic liver failure (ACLF), usually precipitated by alcohol misuse or viral reactivation, is characterised by rapid onset and usually reversible liver failure. Various definitions of ACLF have been proposed and widely used across the globe, including those by APASL, COSSH, EASL-CLIF, Japanese experts, and NACSELD. Although all the definitions have several similarities and connote high short-term mortality, a clear and standardised definition is still lacking, hampering research in this key area. In this review, we discuss the similarities and differences among various definitions and propose steps to harmonise EASL-CLIF, APASL, NACSELD, Japanese, and Chinese definitions of ACLF.

中文翻译：

---

慢性急性肝衰竭——定义统一的步骤！

慢性急性肝衰竭（ACLF）通常由滥用酒精或病毒再激活引起，其特点是发病迅速且通常是可逆性肝衰竭。 ACLF 的各种定义已在全球范围内提出并广泛使用，包括 APASL、COSSH、EASL-CLIF、日本专家和 NACSELD 的定义。尽管所有定义都有一些相似之处，并且都意味着较高的短期死亡率，但仍然缺乏明确和标准化的定义，阻碍了这一关键领域的研究。在这篇综述中，我们讨论了各种定义之间的异同，并提出了协调 EASL-CLIF、APASL、NACSELD、日语和中文 ACLF 定义的步骤。