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The emerging role of tandem repeats in complex traits
Nature Reviews Genetics ( IF 42.7 ) Pub Date : 2024-05-07 , DOI: 10.1038/s41576-024-00736-8
Michael Lamkin , Melissa Gymrek

Tandem repeats are a large source of genetic variation but are challenging to analyse and have been missing from most genome-wide studies. Results now suggest that systematic incorporation of tandem repeats into complex trait analyses is likely to yield a rich source of causal variants and new biological insights. In this Comment, Lamkin and Gymrek discuss recent results that suggest that the systematic incorporation of tandem repeats into complex trait analyses will yield a rich source of causal variants and new biological insights.

中文翻译:

串联重复在复杂性状中的新作用

串联重复是遗传变异的一个重要来源,但分析起来很困难,并且在大多数全基因组研究中都被遗漏了。现在的结果表明,将串联重复系统地纳入复杂性状分析中可能会产生丰富的因果变异来源和新的生物学见解。在这篇评论中,Lamkin 和 Gymrek 讨论了最近的结果,这些结果表明,将串联重复系统地纳入复杂性状分析中将产生丰富的因果变异来源和新的生物学见解。
更新日期:2024-05-07
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