Progress towards the total synthesis of the macrolide natural product anthracimycin is described. This new approach utilises an intermolecular Diels–Alder strategy followed by epimeirsation to form the key trans-decalin framework. The route culminates in the stereoselective synthesis of an advanced tricyclic lactone intermediate, containing five contiguous sterogenic centres with the correct relative and absolute stereochemistry required for the anthracimycin core motif.

中文翻译：

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立体选择性合成先进的反式十氢化萘中间体，用于全合成蒽霉素

描述了大环内酯天然产物蒽霉素的全合成进展。这种新方法利用分子间狄尔斯-阿尔德策略，然后进行表观化学反应，形成关键的反式十氢化萘框架。该路线的最终结果是立体选择性合成先进的三环内酯中间体，该中间体包含五个连续的立体中心，具有蒽霉素核心基序所需的正确的相对和绝对立体化学。