Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.

中文翻译：

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BH4 代谢失调促进胰腺癌的免疫抑制

胰腺导管腺癌（PDAC）是最具侵袭性、恶性和致命性的癌症之一，对免疫治疗表现出很强的抵抗力。在本期《细胞代谢》中，刘等人的一项研究。确定四氢生物蝶呤代谢失调是小鼠和人类免疫抑制 PDAC 环境的关键驱动因素。