Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase’s crucial role in regulating lipid metabolism in CD8⁺ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.

中文翻译：

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靶向代谢回路增强 CD8+ T 细胞抗肿瘤反应

肿瘤通过各种机制损害 T 细胞功能，包括诱导营养匮乏的微环境，导致脂质积累和代谢重编程。亨特等人。阐明乙酰辅酶A羧化酶在调节CD8 ⁺ T细胞脂质代谢中的关键作用，揭示了一种增强抗肿瘤免疫反应的新代谢策略。