Herein, we disclose a highly efficient thermal Ni-catalyzed C–O cross-coupling of aryl halides with primary and secondary alcohols, without the need for photo- or electrocatalysis. The protocol is simple and has a wide substrate scope, particularly for challenging electron-rich aryl halides. Additionally, this methodology has been successfully applied to the late-stage functionalization of drugs and natural products, as well as the synthesis of pharmaceuticals such as pramoxine and the delamanid key intermediate. Preliminary mechanistic studies suggest the in situ generation of active Ni(I) species from inexpensive NiBr₂-bipyridine and PhSiH₃.

中文翻译：

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使用硅烷还原剂方法实现（杂）芳基卤化物与醇的热镍催化碳-氧交叉偶联

在此，我们公开了芳基卤化物与伯醇和仲醇的高效热镍催化C-O交叉偶联，无需光催化或电催化。该方案简单且具有广泛的底物范围，特别是对于具有挑战性的富电子芳基卤化物。此外，该方法已成功应用于药物和天然产物的后期功能化，以及普拉莫辛和德拉马尼关键中间体等药物的合成。初步机理研究表明，可以从廉价的 NiBr ₂ -联吡啶和 PhSiH ₃原位生成活性 Ni(I) 物质。