INTRODUCTIONPlatelets serve as the primary peripheral reservoir of amyloid beta (Aβ). However, there is limited research on platelet markers in routine blood examinations, particularly with regard to the large platelet ratio (P‐LCR) in Alzheimer's disease (AD).METHODSThis study included 512 AD patients and 205 healthy controls (HCs). Platelet markers and apolipoprotein E (APOE) 4 status were assessed in all participants.RESULTSThe study revealed that P‐LCR was significantly elevated in AD patients compared to HCs. In AD patients carrying APOE4, P‐LCR significantly negatively correlated with Montreal Cognitive Assessment scores. There was an observed increasing trend in the rate of change in P‐LCR with disease progression. Binary logistic regression analysis indicated that P‐LCR may constitute a risk factor for AD, after adjusting for age, sex, APOE4, and body mass index.DISCUSSIONP‐LCR is associated with disease severity in AD patients carrying APOE4. P‐LCR may be a promising marker to reflect platelet activity in AD patients.Highlights P‐LCR significantly negatively correlated with MoCA scores in AD patients with APOE4. The rate of change in P‐LCR showed an increasing trend with disease progression. P‐LCR may be a risk factor for AD.

中文翻译：

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阿尔茨海默病外周血血小板标志物与疾病表型的相关性分析

简介 血小板是 β 淀粉样蛋白 (Aβ) 的主要外周储存库。然而，关于常规血液检查中血小板标志物的研究有限，特别是关于阿尔茨海默病 (AD) 中的大血小板比率 (P-LCR)。 方法 本研究包括 512 名 AD 患者和 205 名健康对照 (HC)。血小板标记物和载脂蛋白 E（APOE) 4 对所有参与者的状态进行了评估。结果研究显示，与 HC 患者相比，AD 患者的 P-LCR 显着升高。在 AD 患者中携带APOE如图4所示，P-LCR与蒙特利尔认知评估分数显着负相关。随着疾病进展，P-LCR 的变化率呈增加趋势。二元逻辑回归分析表明，在调整年龄、性别、APOE4、体重指数。讨论 P-LCR 与 AD 患者的疾病严重程度相关APOE4. P-LCR可能是反映AD患者血小板活性的有前景的标志物。亮点 AD 患者的 P-LCR 与 MoCA 评分显着负相关APOE4. 随着疾病进展，P-LCR的变化率呈增加趋势。 P-LCR 可能是 AD 的危险因素。