In this report, we present the dual activation models for transient directing group-directed and amino-self-directed Pd-catalyzed α-aminophosphonate side-chain C(sp³)-H arylation. Both strategies showed facile, efficient, and single regioselectivity in the reaction between free α-aminophosphonates and aryl iodides. Furthermore, the modification of amino and late-stage functionalization of the C(sp³)-P bond from products indicates potential applications for α-aminophosphonates.

中文翻译：

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游离 α-氨基膦酸酯的定向 C(sp3)-H 芳基化：通过钯催化的双重模型探索

在本报告中，我们提出了瞬时导向基团导向和氨基自导向 Pd 催化 α-氨基膦酸酯侧链 C(sp ³ )-H 芳基化的双重激活模型。两种策略在游离 α-氨基膦酸酯和芳基碘化物之间的反应中都显示出简便、有效和单一的区域选择性。此外，产物中氨基的修饰和C(sp ³ )-P键的后期功能化表明了α-氨基膦酸酯的潜在应用。