Molecular imaging with antibodies radiolabeled with positron-emitting radionuclides combines the affinity and selectivity of antibodies with the sensitivity of Positron Emission Tomography (PET). PET imaging allows the visualization and quantification of the biodistribution of the injected radiolabeled antibody, which can be used to characterize specific biological interactions in individual patients. This characterization can provide information about the engagement of the antibody with a molecular target such as receptors present in elevated levels in tumors as well as providing insight into the distribution and clearance of the antibody. Potential applications of clinical PET with radiolabeled antibodies include identifying patients for targeted therapies, characterization of heterogeneous disease, and monitoring treatment response.

中文翻译：

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使用锆 89 去铁敏 B 方酰胺进行诊断性正电子发射断层扫描成像：从实验室到临床

使用正电子发射放射性核素放射性标记的抗体进行分子成像，将抗体的亲和力和选择性与正电子发射断层扫描 (PET) 的灵敏度相结合。 PET 成像可以对注射的放射性标记抗体的生物分布进行可视化和量化，这可用于表征个体患者的特定生物相互作用。这种表征可以提供有关抗体与分子靶点（例如肿瘤中水平升高的受体）结合的信息，并提供对抗体分布和清除的深入了解。放射性标记抗体临床 PET 的潜在应用包括识别患者进行靶向治疗、异质性疾病的表征以及监测治疗反应。