Emerging evidence indicates an association between blood pressure and inflammation, yet this relationship remains unclear in older adults, despite the elevated prevalence of hypertension. We investigated the association between blood pressure, high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and white blood cell (WBC) count in a cohort of 3571 older adults aged 65 and above, and 587 middle-aged participants (55–59 years old). In women aged 65 and above, the relationship between inflammatory markers and blood pressure was consistent, with hs-CRP and WBC emerging as predictors of high blood pressure. For hs-CRP, the adjusted odds ratio (OR) was 1.5 (95% CI, 1.07 to 2.10, P = 0.02), and for WBC, the adjusted OR was 1.41 (95% CI, 1.02 to 1.94, P = 0.04), comparing the highest to the lowest quartiles. In men, only the WBC count was significantly associated with an increased OR for high BP (adjusted OR 1.49, 95% CI, 1.09 to 2.02, P = 0.01) across quartiles. Across the entire study population, in a fully adjusted model, all inflammatory markers were modestly associated with blood pressure levels, while the effect of being over 65 years was the most significant predictor of high blood pressure (OR 1.84, 95% CI, 1.50 to 2.25, P < 0.001). The link between key inflammation markers and blood pressure in older adults varies by sex and biomarker type and may differ from the relationship observed in younger individuals. These relationships are likely to be affected by factors linked to age.

新的证据表明血压与炎症之间存在关联，但尽管高血压患病率升高，但这种关系在老年人中仍不清楚。我们在 3571 名 65 岁及以上老年人的队列中研究了血压、高敏 C 反应蛋白 (hs-CRP)、白细胞介素 6 (IL-6) 和白细胞 (WBC) 计数之间的关联， 587 名中年参与者（55-59 岁）。在 65 岁及以上的女性中，炎症标志物与血压之间的关系是一致的，其中 hs-CRP 和 WBC 成为高血压的预测因子。对于 hs-CRP，调整后的优势比 (OR) 为 1.5（95% CI，1.07 至 2.10，P  = 0.02），对于 WBC，调整后的 OR 为 1.41（95% CI，1.02 至 1.94，P  = 0.04） ，比较最高四分位数与最低四分位数。在男性中，只有 WBC 计数 与各四分位数的高血压 OR 增加显着相关（调整后 OR 1.49，95% CI，1.09 至 2.02，P = 0.01）。在整个研究人群中，在完全调整的模型中，所有炎症标志物都与血压水平有一定的相关性，而年龄超过 65 岁的影响是高血压最显着的预测因素（OR 1.84，95% CI，1.50 至2.25，P  < 0.001）。老年人关键炎症标志物与血压之间的联系因性别和生物标志物类型而异，并且可能与在年轻人中观察到的关系不同。这些关系可能会受到与年龄相关的因素的影响。